{"product_id":"atropine-injection-prefilled-syringe-01-mg-luer-jet-10-ml-pack-of-10-rx","title":"Atropine Injection Prefilled Syringe 0.1 mg Luer-Jet 10 mL, pack of 10 (Rx)","description":"\u003cp\u003eAtropine sulfate is a \u003cstrong\u003epotent anticholinergic (antimuscarinic) drug\u003c\/strong\u003e used in emergency medicine. It blocks acetylcholine at muscarinic receptors throughout the body, thus inhibiting parasympathetic (vagal) activity. In practical terms, atropine \u003cem\u003eincreases heart rate and dries secretions\u003c\/em\u003e. It is formulated for intravenous (or IM) use – often as a 0.1 mg\/mL injection (typically 1 mg in a 10 mL prefilled syringe). According to official prescribing information, “Atropine is a muscarinic antagonist indicated for temporary blockade of severe or life threatening muscarinic effects”. In short, atropine counters dangerous vagal responses, whether in the heart (bradycardia) or elsewhere (excess secretions, bronchospasm, etc.).\u003c\/p\u003e\n\u003cp\u003eSold By the pack of 10.\u003c\/p\u003e\n\u003ch2\u003eIndications and Uses\u003c\/h2\u003e\n\u003cp\u003eAtropine is used in critical care and toxicology settings. Its main FDA-approved roles are to treat \u003cstrong\u003elife-threatening muscarinic overstimulation\u003c\/strong\u003e. Clinically this includes:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSymptomatic bradycardia\/heart block:\u003c\/strong\u003e Atropine is \u003cstrong\u003efirst-line\u003c\/strong\u003e for unstable bradycardia or AV block due to high vagal tone. For example, in advanced cardiac life support (ACLS), IV atropine (0.5–1 mg) is given for symptomatic sinus bradycardia or bradyasystolic arrest. The label notes a \u003cem\u003e1 mg IV\u003c\/em\u003e dose for bradyasystolic cardiac arrest, repeatable every 3–5 minutes if needed. (ACLS guidelines often start at 0.5 mg, but official labeling and many protocols allow 1 mg.)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOrganophosphate\/muscarine poisoning:\u003c\/strong\u003e Atropine is the key antidote for cholinergic pesticide or nerve agent poisoning, and muscarinic mushroom toxicity. Large repeated doses (typically 2–3 mg IV or IM, often much higher in severe cases) are given until pulmonary and secretory symptoms abate. In practice, doses may be titrated to effect (occasionally up to tens of milligrams).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntisialagogue \/ Preanesthetic use:\u003c\/strong\u003e Atropine can be used to reduce excessive salivation and secretions or prevent vagal reflexes during surgery\/intubation. A small dose (about 0.4–0.6 mg IV) is given before anesthesia to dry the airway and stabilize heart rate. (It is often used in pediatric intubations to prevent post-induction bradycardia, since children are more vagal.)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiac arrest (asystole\/PEA):\u003c\/strong\u003e In asystolic or PEA cardiac arrest with a suspected bradycardic\/vagal component, atropine (1 mg IV push) may be tried, per ACLS protocols.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eStatpearls confirms these uses, noting atropine’s FDA indications include anti-vagal (bradycardia) effects, antidote for organophosphates, and reduction of vagal tone\/secretions. Off-label, atropine also clears secretions in intubated patients or pretreatment for bradycardia (e.g. during eye surgery). It is \u003cem\u003enot\u003c\/em\u003e effective in β-blocker overdose or non-vagal causes of bradycardia (glucagon is preferred there), but otherwise can be lifesaving in cholinergic crises and severe bradyarrhythmias.\u003c\/p\u003e\n\u003ch2\u003eMechanism of Action\u003c\/h2\u003e\n\u003cp\u003eAtropine is a \u003cstrong\u003ecompetitive antagonist at muscarinic acetylcholine receptors\u003c\/strong\u003e. By blocking muscarinic receptors (especially M2 receptors in the heart and M3 in glands), atropine prevents acetylcholine’s effects. This leads to removal of parasympathetic tone: the heart rate rises, secretions (saliva, bronchial mucus) decrease, pupils dilate (mydriasis), bronchial smooth muscle relaxes, and gastrointestinal motility slows. For example, \u003cem\u003estatpearls\u003c\/em\u003e explains that atropine “functions as a competitive, reversible antagonist of muscarinic receptors,” causing \u003cstrong\u003eparasympathetic inhibition\u003c\/strong\u003e so that sympathetic effects (like tachycardia) predominate. This direct “vagolytic” action is why atropine can rapidly reverse acute bradycardia or asystole by blocking the vagus nerve’s slowing influence on the heart.\u003c\/p\u003e\n\u003ch2\u003eDosing and Administration\u003c\/h2\u003e\n\u003ch3\u003eAdult Dosing (IV\/IM)\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSymptomatic bradycardia or heart block:\u003c\/strong\u003e Give \u003cstrong\u003e0.5–1 mg IV\u003c\/strong\u003e. Repeat every 3–5 minutes as needed, up to about \u003cstrong\u003e3 mg total\u003c\/strong\u003e. This is most effective for sinus bradycardia and AV nodal block. (Some guidelines use 0.5 mg as first dose, but the product label uses 1 mg for arrest.)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOrganophosphate\/muscarinic poisoning:\u003c\/strong\u003e Give \u003cstrong\u003e2–3 mg IV (or IM)\u003c\/strong\u003e, repeat every 20–30 minutes. Titrate to effect (clearance of secretions, improved breathing); doses may exceed 10–20 mg total if needed.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAntisialagogue (vagal prophylaxis):\u003c\/strong\u003e Give \u003cstrong\u003e0.5–1 mg IV or IM\u003c\/strong\u003e about 30–60 minutes before surgery or intubation. This dose drys secretions and blunts reflex bradycardia.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCardiac arrest (asystole\/PEA with bradycardia):\u003c\/strong\u003e Give \u003cstrong\u003e1 mg IV push\u003c\/strong\u003e; may repeat per ACLS guidelines if there is a continued vagal component.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePediatric dosing:\u003c\/strong\u003e Typically \u003cstrong\u003e0.01–0.03 mg\/kg IV\u003c\/strong\u003e (minimum 0.1 mg), repeat as needed. (In children, bradycardia is often due to hypoxia, so atropine is used only after airway\/ventilation issues are addressed.)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003eAdministration notes:\u003c\/em\u003e Inspect the solution before use; it should be clear. Use aseptic technique. Onset is rapid (IV), peak effect in minutes. Do \u003cstrong\u003enot\u003c\/strong\u003e mix atropine with other drugs in the same syringe or IV line unless compatibility is confirmed. The injection may be given IV push over several seconds, or IM if IV access is not available (onset is slower IM).\u003c\/p\u003e\n\u003ch3\u003eKey Dosage References\u003c\/h3\u003e\n\u003cp\u003eThe official prescribing information and clinical sources align: e.g., one summary states \u003cstrong\u003e“Bradycardia: 1 mg every 3–5 minutes (3 mg max)”\u003c\/strong\u003e, anti-sialagogue \u003cem\u003e0.5–1 mg\u003c\/em\u003e q1–2 h, and \u003cem\u003e“Organophosphate poisoning: 2–3 mg every 20–30 minutes (may require doses up to 20 mg)”\u003c\/em\u003e. These guidelines reflect ACLS and toxicology protocols (repeating atropine doses until desired effect).\u003c\/p\u003e\n\u003ch2\u003eSide Effects and Precautions\u003c\/h2\u003e\n\u003cp\u003eAtropine’s side effects are exactly its expected anticholinergic effects. The most common adverse effects are \u003cstrong\u003edry mouth, blurred vision (due to dilated pupils), photophobia, tachycardia, and flushed, warm skin\u003c\/strong\u003e. Constipation, urinary retention, and decreased sweating (anhidrosis) can also occur, especially in elderly patients. (In overdose or poisoning, these effects intensify – pupils become fully dilated, skin very hot and dry, agitation or delirium may ensue.)\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eImportant precautions:\u003c\/strong\u003e Because atropine increases heart rate and cardiac workload, use caution in patients with coronary artery disease, angina, or heart failure (excessive tachycardia can worsen ischemia). Acute angle-closure glaucoma is a contraindication: pupil dilation can precipitate a dangerous rise in intraocular pressure. Likewise, atropine should be used cautiously if urinary retention or prostatic hypertrophy is present (it can worsen outflow obstruction). Gastrointestinal or urinary obstruction (e.g. paralytic ileus, pyloric stenosis) are also cautions due to reduced motility. \u003cstrong\u003ePregnancy\/lactation:\u003c\/strong\u003e Atropine crosses the placenta and may cause fetal tachycardia, but no birth defects have been observed. It can be given if clearly needed during pregnancy. ACOG advises that \u003cstrong\u003evigorous treatment of maternal bradycardia (e.g. during obstetric procedures) should not withhold atropine\u003c\/strong\u003e. Atropine appears in breast milk in small amounts; mothers should be monitored for reduced infant feeding or drowsiness if used chronically.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMonitoring:\u003c\/strong\u003e Patients on IV atropine (especially older or cardiac patients) should have ECG monitoring due to risk of arrhythmias. Monitor heart rate, blood pressure, and signs of ischemia. In organophosphate poisoning, monitor secretions and mental status to assess if atropine dosing is adequate. Check urinary output, as atropine’s antidiuresis can lead to fluid retention or dilute hyponatremia during infusion.\u003c\/p\u003e\n\u003ch2\u003eStorage and Handling\u003c\/h2\u003e\n\u003cp\u003eAtropine sulfate injection is supplied as a clear, colorless solution (e.g. 0.1 mg\/mL in a glass syringe). Store at controlled room temperature – generally \u003cstrong\u003e20–25°C (68–77°F)\u003c\/strong\u003e (short excursions 15–30°C are allowed). Protect from light, and do not freeze. Do \u003cem\u003enot\u003c\/em\u003e use past the expiration date. Each syringe or vial is single-use: discard any opened, unused portion. Before administration, inspect visually to confirm clarity and no particulate matter.\u003c\/p\u003e\n\u003cp\u003eAtropine sulfate is a fast-acting muscarinic blocker used in emergencies to counteract life-threatening vagal effects. By blocking parasympathetic tone, it \u003cstrong\u003eraises pulse and dries secretions\u003c\/strong\u003e. Typical uses are for \u003cstrong\u003esymptomatic bradycardia (ACLS), asystolic arrest, organophosphate\/muscarinic poisoning, and pre-anesthetic anti-vagal premedication\u003c\/strong\u003e. Adult IV dosing is usually 0.5–1 mg (repeat as needed), and much larger repeated doses are used in poisonings. Side effects (dry mouth, tachycardia, blurred vision) reflect its anticholinergic action so use caution in glaucoma, urinary retention, and cardiac disease. Proper storage (room temperature) and dilution (already premixed) ensure safe administratio. In sum, atropine sulfate injection is an essential emergency drug for reversible cholinergic crises and severe bradycardia, provided in ready-to-use sterile syringes.\u003c\/p\u003e","brand":"International Medication Systems","offers":[{"title":"Default Title","offer_id":50659741860032,"sku":"meg1793474772175","price":171.75,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0762\/7381\/1648\/files\/atropine-injection-prefilled-syringe-01-mg-luer-jet-10-ml-pack-of-10-rx_1.jpg?v=1793474785","url":"https:\/\/lucycatbed.shop\/products\/atropine-injection-prefilled-syringe-01-mg-luer-jet-10-ml-pack-of-10-rx","provider":"My Store","version":"1.0","type":"link"}